3D Bioprinting Living Cells with a Graphene-embedded Electro-Conductive Bioink for Neural Engineering Applications

Referencia Apresentador Autores
Tolou Shokuhfar Nezhad, S.S.(University of Illinois at Chicago); Shokuhfar, T.(University of Illinois at Chicago); 3D Bioprinting provides the opportunity to precisely deposit biomaterials and living cells simultaneously to form desired structures such living scaffolds with precise control over pore interconnection, structure symmetry and forming composites which was not possible using other techniques. This requires using a category of materials known as bio-inks, which can provide biocompatibility for housing cells as well as printability. Depending on applications, bio-inks can be tailored to provide different properties including tissue regeneration, photo responsivity, electrical conductivity or even in some cases biologically inertness. Therefore, one of the most important parts of bioprinting process is developing a bio-ink which can provide all required properties. In this research we developed a new bio-ink with embedded modified graphed oxide nano plates to make it electrically conductive. Also this Methacrylated gelatin based bio-ink can contain and support live cells during and after printing process, which by being electrically conductive at the same time would provide an exciting application for neural engineering. Herein we present a newly developed graphene embedded bioink with desired rheological behavior, ink consistency, mechanical properties, degradation and cell compatibility to conform biological and mechanical requirements necessary as a bio-ink for this composite.
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