Cartilage, bone and joint regeneration using biomaterials, stem cells and 3D bioprinting

Referencia Apresentador Autores
Daniel John Kelly Kelly, D.J.(Trinity College of Dublin); Our musculoskeletal system has a limited capacity for repair. This has led to increased interest in the development of tissue engineering strategies for the regeneration of musculoskeletal tissues such as bone, ligament, tendon, meniscus and articular cartilage. This talk will review our attempts to use biomaterials and mesenchymal stem cells (MSCs) to tissue engineer functional articular cartilage and bone grafts for use in bone and joint regeneration. It will first outline our work developing single-stage or point-of-care strategies for regenerating damaged tissues. These strategies aim to maximise our body’s inherent potential for regeneration. The talk will then describe how our lab is using novel in vitro models to systematically investigate how MSCs respond to their local biophysical and biochemical environment. Demonstrations of how this information can be leveraged to engineer functional cartilage and bone grafts will be provided. The talk will conclude with a demonstration of how we can integrate biomaterials and MSCs into 3D bioprinting systems to engineer scaled-up tissues that could potentially be used regenerate entire bone organs or diseased joints.
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